The half-elimination time of this active form is between 7 and 14 days. Further metabolism also occurs in the kidneys, including the formation of the 1, 24, 25-trihydroxy derivatives. Ergocalciferol is hydroxylated in the liver by the enzyme Vitamin D 25-hydroxylase to form 25-hydroxyergocalciferol which undergo further hydroxylation in the kidneys by the enzyme Vitamin D1-hydroxylase to form the active metabolite 1, 25-dihydroxyergocalciferol. The half-elimination time of Vitamin D is 26 hours. It is slowly released from such storage sites and from the skin where it is formed in the presence of sunlight or ultraviolet light. Ergocalciferol have a slow onset and a long duration of action. Vitamin D can be stored in adipose and muscle tissue for long period of time. Vitamin D2 and its metabolites circulates in the blood bound to a specific alpha-globulin. Its absorption depends on the functional condition of the pancreas and is strongly reduced in the presence of steatorrhea. Vitamin D is absorbed in the jejunum wall and as calciferol crosses into the blood plasma and lymph.

It regulates : phosphorus-calcium metabolism and the processes of ossification absorption of phosphorus and amino acids in renal tubules. are white coloured, circular film coated tablets.Įrgocalciferol has the highest activity from the group of Vitamin D.

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